Katedra za farmaceutsku hemiju

Historija Katedre

Katedra za farmaceutsku hemiju osnovana je na Farmaceutskom fakultetu 1975/76. godine, a prva profesorica bila je prof. dr. Blanka Bobarević, tada redovni profesor na Medicinskom fakultetu u Sarajevu. Zbog opravdanog odsustva prof. dr. Blanke Bobarević predavanja prvoj generaciji studenata Farmaceutskog fakulteta držala je prof. dr. Zorka Blagojević, redovni profesor iz Beograda. Prvi asistenti na Katedri bili su mr. ph. Emira Burunčević-Bilalović (od 1976. do 2003. godine) i mr. ph. Fina Albahari-Lovren (od 1989. do 1992. godine).

Mr. sc. Emira Burunčević-Bilalović bila je rukovodilac Laboratorije za izolaciju i derivatizaciju anaboličkih steroida na XIV ZOI u Sarajevu, pa je u okviru priprema za akreditaciju Laboratorija za doping-kontrolu na XIV ZOI boravila na usavršavanju u Kelnu, Beogradu i Beču u periodu 1982–1983.

Po odlasku u penziju prof. dr. Blanke Bobarević 1987. godine kao nastavnik je angažovan doc. dr. Sote Vladimirov iz Beograda. Rukovoditeljica Katedre u periodu 1989–1992. bila je doc. dr. Fina Albahari. U periodu agresije na Bosnu i Hercegovinu od 1993. do 1995. nastavu je vodila doc. dr. Meliha Lekić, docent Medicinskog fakulteta u Sarajevu. U periodu 1996–2002. kao gostujući profesor na Katedri bila je prof. dr. Marica Medić-Šarić, vanredni profesor farmaceutske hemije Sveučilišta u Zagrebu. Godine 1997. Katedra dobija još jednog asistenta – Samiju Muratović, mr. ph. U ovim za Katedru turbulentnim vremenima za stalnog nastavnika 2002. godine izabrana je doc. dr. Davorka Završnik. U godinama koje slijede Katedra dobija još 3 asistenta: 2003. godine Selmu Špirtović, mr. ph., 2007. godine Elmu Veljović, mr. ph., i 2012. godine Amara Osmanovića, mr. ph. U periodu 2009–2012. nastavnici i saradnici Katedre učestvovali su u velikom međunarodnom projektu u kome su bile Švicarska, Hrvatska i Bosna i Hercegovina (Development of Acyclic Pyrimidine Analogues as PET –Tracer for Monitoring Gene Therapy. Projekat SCOPES 2009–2012). Voditelj ovog projekta za Bosnu i Hercegovinu bila je prof. dr. Davorka Završnik. Iz projekta je Katedra prvi put poslije 1995. godine dobila značajnija finansijska sredstva za nabavku opreme i hemikalija. Od 2019. do 2021. godine rukovoditeljica Katedre bila je prof. dr. Samija Muratović. U periodu od 2021. do danas tu ulogu vrši prof. dr. Selma Špirtović-Halilović. Danas Katedra ima dvije redovne profesorice, jednu vanrednu profesoricu, jednog docenta i jednog laboratorijskog tehničara. U momentu pisanja ove monografije u toku su dva naučnoistraživačka projekta, dok se čekaju rezultati aplikacije na još jedan.

Nastavno-naučno i stručno osoblje koje trenutno sudjeluje u nastavi

Prof. dr. Samija Muratović redovna profesorica Google Scholar ORCID CV   |   CV-en	Prof. dr. Selma Špirtović-Halilović redovna profesorica Google Scholar ORCID CV   |   CV-en	Prof. dr. Elma Veljović vanredna profesorica Google Scholar ORCID CV   |   CV-en

Prof. dr. Amar Osmanović vanredni profesor Google Scholar ORCID CV   |   CV-en	Emina Bečić, mr. ph. asistentica  Google Scholar ORCID CV   |   CV-en	Kenan Hodžić laboratorijski tehničar

Nastavna djelatnost

U momentu pisanja ove monografije aktivna su dva nastavna plana i programa za dodiplomsku nastavu: Nastavni plan iz 2015. godine i Nastavni plan iz 2022. godine. U okviru Nastavnog plana iz 2015. godine (pasivnog Nastavnog plana i programa), kada je dodiplomska nastava u pitanju, na trećoj godini kao obavezni predmeti slušaju se Farmaceutska hemija I i Farmaceutska hemija II. Katedra je studentima u okviru ovog nastavnog plana ponudila i tri izborna predmeta na dodiplomskoj nastavi:

Odabrana poglavlja iz Farmaceutske hemije – Dizajniranje lijekova (predmet se sluša na trećoj godini studija);

Odabrana poglavlja iz Farmaceutske hemije – Lijekovi za tretman gripe i prehlade (predmet se sluša na četvrtoj godini studija);

Odabrana poglavlja iz Farmaceutske hemije – Metabolička stabilnost lijekova i strategije za povećanje metaboličke stabilnosti (predmet se sluša na četvrtoj godini studija).

U okviru Nastavnog plana i programa iz 2022. godine (aktivnog Nastavnog plana i programa) studenti u drugoj godini studija slušaju Farmaceutsku hemiju I, dok je Farmaceutska hemija II na trećoj godini studija. Katedra je studentima u okviru ovog nastavnog plana ponudila četiri izborna predmeta na dodiplomskoj nastavi:

Odabrana poglavlja iz Farmaceutske hemije – Dizajniranje lijekova (predmet se sluša na trećoj godini studija);

Odabrana poglavlja iz Farmaceutske hemije – Lijekovi za tretman gripe i prehlade (predmet se sluša na trećoj godini studija);

Odabrana poglavlja iz Farmaceutske hemije – Neurohemija (predmet se sluša na petoj godini studija);

Odabrana poglavlja iz Farmaceutske hemije – Novi lijekovi u tretmanu kardiovaskularnih bolesti (predmet se sluša na petoj godini studija).

Kada je III ciklus studija – doktorski studij u pitanju, Katedra godinama aktivno doprinosi kvaliteti nastave kroz angažman nastavnika na obaveznim i izbornim predmetima i izradom velikog broja doktorskih disertacija s kandidatima.

U trenutku pisanja ove monografije u toku je realizacija nastave na doktorskom studiju za generaciju upisanu 2023. godine. Nastavnici Katedre voditelji su četiri izborna predmeta na aktuelnom doktorskom studiju:

Molekularne osnove farmaceutske hemije;

Otkriće i razvoj lijekova;

Primjena in silico metoda u dizajniranju lijekova;

Dizajn i sinteza novih farmakološki aktivnih spojeva.

Nastavnici Katedre tenutno su supervizori za pet studenata aktuelnog doktorskog studija.

Naučna i stručna djelatnost

Na Katedri za farmaceutsku hemiju razvijen je bogat naučnoistraživački rad, koji rezultira izradom doktorskih disertacija i objavljivanjem radova u renomiranim časopisima, što se može vidjeti iz pojedinačnih bibliografskih podataka uposlenika Katedre. Od osnivanja do danas na Katedri je urađeno šest magistarskih radova, deset doktorskih disertacija, te je objavljen veliki broj naučnih radova.

Istraživanja se provode u sklopu realizacije mnogobrojnih naučnoistraživačkih projekata, kao i saradnje s naučnoistraživačkim institutima i fakultetima, kako u zemlji tako i u inostranstvu, što je navedeno u afilijacijama objavljenih radova. Naučnoistraživački rad na Katedri obuhvata:

• dizajniranje lijekova (2D i 3D QSAR, doking-studije, DFT analize);
• sintezu biološki aktivnih spojeva (derivata kumarina, kinolon karbonskih kiselina, 5-hidroksialkilpirimidina, ksanten-3-on derivata, tetraketona, aminotimokinona i benzopirona);
• karaterizaciju upotrebom sofisticiranih analitičkih metoda (IR,¹H/¹³C-NMR, MAS, X-ray);
• ispitivanje fizičko-hemijskih osobina novosintetiziranih spojeva i genotoksičnosti;
• ispitivanje njihove biološke aktivnosti (antibakterijske, antiviralne, antitumorske, antiagregacijske, analgetske);
• ispitivanje utjecaja novosintetiziranih spojeva na aktivnost enzima (CIP, tirozinaza).

Članovi Katedre bili su aktivni i na više međunarodnih COST akcija (članovi upravnih odbora ispred BiH, članovi radnih grupa): EURESTOP – European Network for diagnosis and treatment of antibiotic-resistant bacterial infections (trenutno aktivna), INNOGLY – Innovation with Glycans: new frontiers from synthesis to new biological targets (završena), UNGAP – European Network on Understanding Gastrointestinal Absorption-related processes (završena).

Članovi Katedre također redovno učestvuju na međunarodnim konferencijama, kongresima i trening školama (Portugal, Španija, Italija, Holandija, Belgija, Bosna i Hercegovina), gdje su bili i trenutno su članovi naučnih i organizacijskih odbora. Značajna je i aktivnost članova Karedre u stručnim komisijama pri Federalnom i Kantonalnom ministarstvu zdravlja.

DEPARTMENT OF PHARMACEUTICAL CHEMISTRY

History of the Department

The Department of Pharmaceutical Chemistry was established at the Faculty of Pharmacy in 1975/76, and the first professor was professor Blanka Bobarević, a full professor at the Faculty of Medicine in Sarajevo. Due to the justified absence of professor Blanka Bobarević, the lecture to the first generation of students of the Faculty of Pharmacy was held by professor Zorka Blagojević, a full professor from Belgrade. The first teaching assistants at the Department were MPharm Emira Burunčević-Bilalović (from 1976 to 2003) and MPharm Fina Albahari-Lovren (from 1989 to 1992).

Emira Bilalović, M.Sc., was the head of the Laboratory for Isolation and Derivatization of Anabolic Steroids at the XIV Winter Olympics in Sarajevo, so as part of the preparations for the accreditation of the laboratory for doping control at the XIV Winter Olympics, she attended training in Cologne, Belgrade and Vienna in the period 1982–1983.

After the retirement of professor Blanka Bobarević in 1987, assistant professor Sote Vladimirov from Belgrade was hired as a teacher. The head of the Department in the period 1989–1992 was assistant professor Fina Albahari. During the period of war from 1993 to 1996, classes were delivered by Meliha Lekić, assistant professor at the Faculty of Medicine in Sarajevo. In the period 1996–2002,  professor Marica Medić-Šarić, associate professor of Pharmaceutical Chemistry, University of Zagreb was a visiting professor at the Department,. In 1997, the Department hired another teaching assistant, Samija Muratović, Mpharm. In these turbulent times, in 2002, a new assistant professor was elected, professor Davorka Završnik. In the following years, the Department employed three more teaching assistants: in 2003, Selma Špirtović, MPharm, in 2007, Elma Veljović, MPharm. and in 2012, Amar Osmanović, MPharm. In the period 2009–2012, teachers and teaching assistants of the Department participated in a large international project, which included Switzerland, Croatia and Bosnia and Herzegovina participated (Development of Acyclic Pyrimidine Analogues as PET – Tracer for Monitoring Gene Therapy. SCOPES Project 2009–2012). The leader of this project for B&H was professor Davorka Završnik. From this project, for the first time since 1995, the Department received significant financial resources for the purchase of equipment and chemicals. From 2019 to 2021, the head of the Department was professor Samija Muratović. In the period from 2021 until today, the position is held by professor Selma Špirtović-Halilović. Today, the Department has two full professors, one associate professor, one assistant professor and one laboratory technician. At the time of writing this monograph, two research projects are in progress, while the results of the application for another one are awaited.

Teaching and professional staff currently involved in the teaching process

• Professor Emeritus Davorka Završnik, from 2002
• Full Professor Samija Muratović, from 1997
• Full Professor Selma Špirtović-Halilović, from 2003
• Associate Professor Elma Veljović, from 2007
• Associate Professor Amar Osmanović, from 2012
• Kenan Hodžić, laboratory technician, from 2003

Teaching activities

At the time of writing this monograph, two curricula for undergraduate program are in force: the 2015 curriculum and the 2022 curriculum. As part of the curriculum of 2015 (passive curriculum), when it comes to undergraduate program, Pharmaceutical Chemistry I and Pharmaceutical Chemistry II are compulsory courses in the third year. Within the framework of this curriculum, the department also offers students three elective courses at the undergraduate level:

Selected chapters from Pharmaceutical Chemistry – Drug Design (the course is taken in the third year of study);

Selected chapters from Pharmaceutical Chemistry – Drugs for the treatment of flu and colds (the course is taken in the fourth year of study);

Selected chapters from Pharmaceutical Chemistry – Metabolic stability of drugs and strategies for increasing metabolic stability (the course is taken in the fourth year of study).

Within the curriculum of 2022 (active curriculum), students in the second year of study take Pharmaceutical Chemistry I, while classes in Pharmaceutical Chemistry II are delivered in the third year of study. Within the framework of this curriculum, the department offers students four elective courses at the undergraduate level:

Selected chapters from Pharmaceutical Chemistry – Drug Design (the course is taken in the third year of study);

Selected chapters from Pharmaceutical Chemistry – Drugs for the treatment of flu and colds (the course is taken in the third year of study);

Selected chapters from Pharmaceutical Chemistry – Neurochemistry (the course is taken in the fifth year of studies);

Selected chapters from Pharmaceutical Chemistry – New drugs in the treatment of cardiovascular diseases (the course is taken in the fifth year of study).

When it comes to doctoral studies, the Department has been actively contributing to the quality of teaching for years through the involvement of teachers in compulsory and elective courses and the preparation of a large number of doctoral dissertations with candidates.

At the time of writing this monograph doctoral studies, which started in 2023 are in progress,. The teachers of the Department are the leaders of four elective courses in the current doctoral studies:

Molecular basis of pharmaceutical chemistry;

Drug discovery and development;

Application of in silico methods in drug design;

Design and synthesis of new pharmacologically active compounds.

The teachers of the Department are currently supervisors for five students of the current doctoral study.

Academic and professional activities

At the Department of Pharmaceutical Chemistry, rich research activities have developed, which has resulted in the production of doctoral dissertations and publication of papers in renowned journals, which can be seen from the individual bibliographic data of the Department's employees. Since its establishment, six master's theses, ten doctoral theses, and a large number ofacademic papers have been published at the Department.

Research is carried out as part of numerous research projects, as well as cooperation with research institutes and faculties, both in the country and abroad, which is indicated in the affiliations of published works. Research at the Department includes:

• drug design (2D and 3D QSAR, docking studies, DFT analyses);
• synthesis of biologically active compounds (coumarin derivatives, quinolone carboxylic acids, 5-hydroxyalkylpyrimidines, xanthen-3-one derivatives, tetraketones, aminothymoquinones and benzopyrones);
• characterization using sophisticated analytical methods (IR, 1H/13C-NMR, MAS, X-ray);
• research of physico-chemical properties and genotoxicity of newly synthesized compounds;
• research of their biological activity (antibacterial, antiviral, antitumor, anti-aggregation, analgesic);
• research of the effect of newly synthesized compounds on enzyme activity (CYP, tyrosinase).

The members of the Department were also active in several international COST actions (members of management committees representing BiH, members of working groups): EURESTOP – European Network for diagnosis and treatment of antibiotic-resistant bacterial infections (currently active), INNOGLY – Innovation with Glycans: new frontiers from synthesis to new biological targets (completed), UNGAP – European Network on Understanding Gastrointestinal Absorption-related processes (completed). Members of the Department also regularly participate in international conferences, congresses and training schools (Portugal, Spain, Italy, Netherlands, Belgium, Bosnia and Herzegovina) where they were and currently are members of scientific and organizational committees. The activity of Department members in expert commissions at the Federal and Cantonal Ministry of Health is also significant.