Katedra za farmaceutsku tehnologiju

Historija Katedre

Katedra je osnovana na Farmaceutskom fakultetu 1975/76. godine, kada su zbog nedostatka nastavnog kadra nastavu izvodili profesori Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu. U tom periodu održavana je nastava iz predmeta Farmaceutska tehnologija, koji se kao jedan predmet izučavao tokom dva semestra na četvrtoj godini studija. Uključivao je teorijsku, praktičnu i kontroliranu nastavu, te završni usmeni ispit. Praktična nastava jednim dijelom odvijala se u prostorijama Apoteke „Koševo“, dok se industrijski dio praktične nastave provodio u „Bosnalijeku“.

Počevši od akademske 1978/79, zbog narušenog zdravstvenog stanja dotadašnjeg nastavnika prof. dr. Ivana Štivića, izvođenje nastave na Katedri za farmaceutsku tehnologiju preuzima Katedra za farmaceutsku tehnologiju Farmaceutskog fakulteta Univerziteta u Beogradu.

Od akademske 1981/82. za Katedru i cjelokupan program nastave na predmetu Farmaceutska tehnologija postaje odgovorna doc. dr. Sabira Hadžović, koja je do tog momenta vodila industrijski dio praktične nastave, a na poziciji rukovoditeljice Katedre zadržala se do odlaska u mirovinu 2001. godine.

Zahvaljujući usvajanju inoviranog programa nastave u 1991. godini studij na Farmaceutskom fakultetu počinje trajati pet godina i završava se diplomskim radom. Navedena izmjena programa nastave rezultirala je izučavanjem dvaju kolegija na Katedri za farmaceutsku tehnologiju. Nekadašnji dvosemestralni predmet Farmaceutska tehnologija tada biva konvertiran u Farmaceutsku tehnologiju I i Farmaceutsku tehnologiju II, koji se izučavaju na IV i V godini studija.

Nakon usvajanja novog Nastavnog plana i programa 1998. godine kolegij Farmaceutska tehnologija I preimenovan je u kolegij Oblikovanje lijekova, dok je kolegij Farmaceutska tehnologija II preimenovan u kolegij Industrijska farmacija.

Kada je zbog prihvatanja principa bolonjskog sistema studiranja na Univerzitetu u Sarajevu usvojen inovirani Nastavni plan i program 2009/2010. godine, svi predmeti koji se izučavaju na Katedri postaju jednosemestralni i uvode se izborni predmeti. Kao redovni predmeti izučavaju se Oblikovanje lijekova I u VII semestru, Oblikovanje lijekova II i Industrijska farmacija I u VIII semestru, te Industrijska farmacija II u IX semestru. U okviru Katedre izučavaju se izborni predmeti Odabrana poglavlja iz Oblikovanja lijekova – Kozmetologija u VIII semestru, Odabrana poglavlja iz Industrijske farmacije – Stabilnost u IX semestru, te od akademske 2015/2016. i predmet Odabrana poglavlja iz Oblikovanja lijekova – Certifikacijski standardi u apoteci.

Nastavno-naučno i stručno osoblje koje trenutno sudjeluje u nastavi

Prof. dr. Edina Vranić redovna profesorica Google Scholar ORCID CV   |   CV-en	Prof. dr. Jasmina Hadžiabdić vanredna profesorica Google Scholar ORCID CV   |   CV-en	Prof. dr. Ognjenka Rahić vanredna profesorica Google Scholar ORCID CV   |   CV-en	Prof. dr. Alisa Elezović vanredna profesorica Google Scholar ORCID CV   |   CV-en

Lamija Hindija, mr. ph. viša asistentica Google Scholar ORCID CV   |   CV-en	Merima Šahinović, mr. ph.  viša asistentica Google Scholar ORCID CV   |   CV-en	Amina Tucak-Smajić, mr. ph. viša asistentica Google Scholar ORCID CV   |   CV-en

Nastavna djelatnost

Katedra za farmaceutsku tehnologiju na Univerzitetu u Sarajevu – Farmaceutskom fakultetu zadužena je za razvoj i izvođenje sljedećih predmeta u okviru naučne oblasti farmaceutska tehnologija: Oblikovanje lijekova I, Oblikovanje lijekova II, Odabrana poglavlja iz oblikovanja lijekova – Kozmetologija, Odabrana poglavlja iz oblikovanja lijekova – Certifikacijski standardi u apoteci, Industrijska farmacija I, Industrijska farmacija II, Odabrana poglavlja iz industrijske farmacije – Stabilnost lijekova.

Zahvaljujući preciziranim ciljevima navedenih predmeta studenti razumijevaju metodologiju i osposobljavaju se za formuliranje, izradu, vrednovanje, pravilan način primjene i metode uzorkovanja standardnih i savremenih farmaceutskih oblika, kozmetičkih te ekstraktivnih preparata, kako u laboratorijskom tako i u industrijskom opsegu. Navedenim se osigurava osnova za originalno razvijanje ideja i daljnju nadgradnju. Studenti se osposobljavaju da prepoznaju i primjenjuju zakonske smjernice i pravila dobrih praksi u razvoju, proizvodnji i testiranju lijekova u industrijskom opsegu, kao i važeće smjernice za testiranje stabilnosti. Na taj se način stvara mogućnost poređenja i odabira adekvatne farmaceutsko-tehnološke operacije u proizvodnji, te predviđanja eventualnih problema, kao i predlaganja rješenja u toku proizvodnog procesa. Ovako stečena znanja osposobljavaju studenta za rad na razvoju, formulaciji, pretformulaciji i karakterizaciji farmaceutskih oblika, procjeni njihove stabilnosti (roka trajanja, načina pakovanja i uslova čuvanja) i biofarmaceutskoj karakterizaciji.

Pored provođenja nastave na dodiplomskom studiju Katedra za farmaceutsku tehnologiju provodi nastavu i u okviru III ciklusa studija počevši od njegovog osnivanja 2014. godine. Nastava obuhvata sljedeće predmete u okviru naučne oblasti farmaceutska tehnologija: Pretformulacijske studije i razvoj farmaceutskih oblika, Odabrana poglavlja iz fizikalne farmacije, Savremeni farmaceutski oblici i Odabrana poglavlja iz kozmetologije.

Ishodi učenja navedenih predmeta obuhvataju savladavanje metodologije i principa pretformulacijskih studija i razvoja farmaceutskih oblika, poboljšanja topivosti teško topivih supstanci, izrade savremenih farmaceutskih oblika. Sposobnost samostalnog razmatranja, definiranja i rješavanje problema značajnih za pretformulacijske studije i razvoj farmaceutskih oblika, uključujući i poboljšanje topivosti teško topivih supstanci, savremene farmaceutske oblike i kozmetičke proizvode, njihovu karakterizaciju, sposobnost rješavanja konkretnih problema primjenom naučnih metoda i postupaka, te tehnologije proizvodnje različitih kozmetičkih proizvoda i dermatokozmetičkih preparata.

Program cjeloživotnog učenja „Formulab: formuliranje preparata za njegu kože“ kreirala je i pokrenula prof. dr. Alisa Elezović 2019. godine, a namijenjen je visokoobrazovanom kadru, prvenstveno magistrima farmacije. Cilj je ojačati domaće kapacitete na polju razvoja novih formulacija kozmetičkih preparata, te njihove proizvodnje i stavljanja na tržište, kako na domaće tako i na svjetsko. S obzirom na ovaj krovni cilj, specifični ciljevi programa jesu obuka polaznika praktičnim pristupom o poznavanju materijala i tehnologija izrade kozmetike za njegu kože, mogućnostima kreiranja novih kozmetičkih proizvoda, osnovnim zahtjevima kvaliteta prije stavljanja preparata na tržište, te involviranosti formulatora u marketing proizvoda.

Pored aktivnosti u obrazovanju Katedra za farmaceutsku tehnologiju bavi se naučnim, zdravstvenim i profesionalnim aktivnostima. Katedra organizira specijalističke studije iz farmaceutske tehnologije, koju zahtijeva sistem zdravstvene zaštite.

Naučna i stručna djelatnost

Naučna i stručna djelatnost Katedre za farmaceutsku tehnologiju usmjerena je na razvoj i karakterizaciju savremenih oblika doziranja lijekova, kako s trenutnim tako i s kontroliranim oslobađanjem aktivne supstance. Glavna područja istraživanja obuhvataju:

• pretformulacijska ispitivanja aktivnih supstanci (DSC, TGA, HSM, studije kompatibilnosti, reološka ispitivanja);
• metode poboljšanja topivosti teško topivih supstanci (kompleksiranje, čvrste disperzije);
• formulacijske studije i formuliranje čvrstih oblika doziranja (tablete, pelete, kapsule);
• formulacijske studije i formuliranje oblika doziranja s kontroliranim i pulsirajućim oslobađanjem aktivne supstance;
• formulacijske studije i formuliranje tečnih i polučvrstih farmaceutskih oblika (suspenzije, emulzije, mikroemulzije, mikroklizme, ljekoviti lakovi za nokte) i kozmetičkih preparata;
• razvoj metoda za pretformulacijska i formulacijska ispitivanja aktivnih i pomoćnih supstanci, poluproizvoda i gotovih proizvoda (ispitivanje permeacije kroz prirodne i vještačke membrane, metode određivanja oslobađanja aktivne supstance iz ljekovitog oblika);
• in vitro ispitivanja čvrstih, polučvrstih i tečnih oblika doziranja;
• nanostrukturirane materijale.

DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY

History of the Department

The Department was established at the Faculty of Pharmacy in the 1975/76 academic year when, due to a shortage of teaching staff, classes were delivered by professors from the Faculty of Pharmacy at the University of Zagreb. During that period, lectures were held in the course Pharmaceutical Technology, which was studied as a single course over two semesters in the fourth year of study. The course included theoretical, practical, and controlled instruction, as well as a final oral examination. Internship took place partly on the premises of the ‘Koševo’ pharmacy, while the industrial part of internship was organized at ‘Bosnalijek’.

Starting from the 1978/79 academic year, due to the deteriorating health of the previous instructor, Full Professor Ivan Štivić, the teaching responsibilities for the Department of Pharmaceutical Technology were taken over by the Department of Pharmaceutical Technology at the Faculty of Pharmacy, University of Belgrade.

Starting from the 1981/82 academic year, Assistant Professor. Sabira Hadžović assumed responsibility for the Department and the entire curriculum related to the subject of Pharmaceutical Technology. She had previously headed the industrial part of internship and remained in the position of department head until her retirement in 2001.

Thanks to the adoption of an innovative curriculum in 1991, the study program at the Faculty of Pharmacy extended to five years and concluded with a master’s thesis. This change in the curriculum led to the study of two courses within the Department of Pharmaceutical Technology. The former two-semester course Pharmaceutical Technology was then split into Pharmaceutical Technology I and Pharmaceutical Technology II, which are studied in the fourth and fifth years of study.

After the adoption of a new curriculum in 1998, the course Pharmaceutical Technology I was renamed to Drug Formulation, while Pharmaceutical Technology II became Industrial Pharmacy.

Subsequently, due to the implementation of the Bologna-based system of education at the University of Sarajevo, an updated curriculum was adopted in the 2009/2010 academic year. All courses taught within the department became one-semester courses, and elective ones were introduced. Compulsory courses include Drug Formulation I in the seventh semester, Drug Formulation II and Industrial Pharmacy I in the eighth semester, and Industrial Pharmacy II in the ninth semester. Elective courses within the department cover topics such as Selected Topics in Drug Formulation – Cosmetology in the eighth semester and Selected Topics in Industrial Pharmacy – Stability in the ninth semester. Additionally, starting from the 2015/2016 academic year, the course Selected Topics in Drug Formulation – Certification Standards in Pharmacy is also offered.

Teaching and professional staff currently involved in the teaching process

• Full Professor Edina Vranić, from 1994
• Associate Professor Jasmina Hadžiabdić, from 1996
• Associate Professor Ognjenka Rahić, from 2008
• Associate Professor Alisa Elezović, from 2005
• Senior Teaching and Research Assistant Lamija Hindija, MPharm., from 2018
• Senior Teaching and Research Assistant Merima Šahinović, MPharm., from 2018
• Senior Teaching and Research Assistant Amina Tucak-Smajić, MPharm., from 2018

Teaching activities

The Department of Pharmaceutical Technology at the University of Sarajevo – Faculty of Pharmacy is responsible for the development and delivery of the following courses within the scientific area of Pharmaceutical Technology: Drug Formulation I, Drug Formulation II, Selected Topics in Drug Formulation – Cosmetology, Selected Topics in Drug Formulation – Certification Standards in Pharmacy, Industrial Pharmacy I, Industrial Pharmacy II, and Selected Topics in Industrial Pharmacy – Drug Stability.

Thanks to the precise objectives of these courses, students become able to understand the methodology and are trained in formulating, manufacturing, evaluating, proper administration methods, and sampling techniques for standard and contemporary pharmaceutical forms, cosmetics, and extractive preparations, both in laboratory and industrial settings. This provides a foundation for original idea development and further advancement. Students become able to recognize and apply legal guidelines and good practices in the development, production, and testing of drugs on an industrial scale, as well as relevant stability testing guidelines. This enables the comparison and selection of appropriate pharmaceutical-technological operations in production, prediction of potential issues, and proposing solutions during the production process. The knowledge acquired in this way prepares students to work on the development, formulation, pre-formulation, and characterization of pharmaceutical forms, as well as assessing their stability (shelf life, packaging methods, and storage conditions) and bio-pharmaceutical characterization.

In addition to being involved in undergraduate education, the Department of Pharmaceutical Technology also offers courses within the framework of the third cycle of studies, starting from its establishment in 2014. The courses cover the following subjects in the scientific area of Pharmaceutical Technology: Preformulation studies and development of pharmaceutical forms, Selected chapters in physical pharmacy, Contemporary pharmaceutical forms, and Selected chapters in cosmetology.

The learning outcomes of these courses include mastering the methodology and principles of preformulation studies and pharmaceutical form development, improving the solubility of poorly soluble substances, and creating contemporary pharmaceutical forms. Students gain the ability to independently analyze, define, and solve problems relevant to preformulation studies and pharmaceutical form development, including enhancing the solubility of poorly soluble substances, modern pharmaceutical forms, and cosmetic products. Additionally, they acquire the skills to address specific issues using scientific methods and procedures, as well as the technology for manufacturing various cosmetic products and dermocosmetic preparations

The lifelong learning program „Formulab: formulation of skin care products“ was created and launched by Associate Professor Alisa Elezović in 2019, and it is intended for highly educated professionals, primarily masters of pharmacy. The aim is to strengthen domestic capacities in the field of developing new formulations of cosmetic preparations, as well as their production and marketing, both nationally and internationally. With regard to this overarching goal, the specific goals of the program are to train participants with a practical approach to knowledge of the materials and technologies for the production of skin care cosmetics, the possibilities of creating new cosmetic products, the basic quality requirements before placing the product on the market, and the involvement of formulators in product marketing.

In addition to educational activities, the Department of Pharmaceutical Technology is engaged in scientific, health-related, and professional activities. The department organizes specialized studies in pharmaceutical technology, which are required by the healthcare system.

Academic and professional activities

The academic and professional activities of the Department of Pharmaceutical Technology are focused on the development and characterization of modern drug dosage forms, both immediate-release and controlled-release formulations. The main research areas include:

• preformulation studies of active substances (DSC, TGA, HSM, compatibility studies, rheological testing);
• methods for improving the solubility of poorly soluble substances (complexation, solid dispersions);
• formulation studies and development of solid dosage forms (tablets, pellets, capsules);
• formulation studies and development of dosage forms with controlled and pulsatile drug release;
• formulation studies and development of liquid and semi-solid pharmaceutical forms (suspensions, emulsions, microemulsions, microclysters, medicated nail lacquers) and cosmetic preparations;
• development of methods for preformulation and formulation testing of active and auxiliary substances, intermediates, and finished products (permeation testing through natural and artificial membranes, methods for determining drug release from medicinal forms);
• in vitro testing of solid, semi-solid, and liquid dosage forms;
• nanostructured materials

.